منابع مشابه
Insulin Resistance: Molecular Mechanism
Insulin resistance in skeletal muscle is present in humans with type 2 diabetes (non-insulin dependent diabetes mellitus) and obesity and in rodents with these disorders. Malonyl CoA is a regulator of carnitine palmitoyl transferase l (CAP I), the enzyme that controls the transfer of long chain fatty acyl CoA into mitochondria, where it is oxidized. In rat skeletal muscle, the formation of malo...
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"Insulin-resistance" is the hallmark of Type 2 Diabetes Mellitus, as well as of the "Metabolic Syndrome" which is considered to be the "pre-diabetic" form of Type 2 Diabetes Mellitus. In Metabolic Syndrome the blood sugar level is normal, but the insulin level keeping it there is higher than normal. It becomes Type 2 Diabetes Mellitus when the early morning (pre-breakfast) blood sugar level is ...
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Insulin resistance is proposed to be causally related to the metabolic syndrome disorders, but a direct cause-and-effect relationship between insulin resistance and hypertension was not originally obvious. Previous data suggested that insulin promotes sodium retention from the kidney, and thus research efforts focused on this action among several other possible pathways connecting insulin resis...
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To examine the mechanism by which lipids cause insulin resistance in humans, skeletal muscle glycogen and glucose-6-phosphate concentrations were measured every 15 min by simultaneous 13C and 31P nuclear magnetic resonance spectroscopy in nine healthy subjects in the presence of low (0.18 +/- 0.02 mM [mean +/- SEM]; control) or high (1.93 +/- 0.04 mM; lipid infusion) plasma free fatty acid leve...
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ژورنال
عنوان ژورنال: Nature Reviews Endocrinology
سال: 2016
ISSN: 1759-5029,1759-5037
DOI: 10.1038/nrendo.2016.46